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KAT5 (Histone acetyltransferase KAT5) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumour suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.87, genetic association 0.00, somatic mutation 0.00).
In plain words · KAT5 (Histone acetyltransferase KAT5) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
KAT5 (Histone acetyltransferase KAT5) is a protein that switches other genes on and off. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4.
No product in this corpus aims at KAT5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Kamine et al, Virology, 1996, "Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator". Source.
Sources: HGNC HGNC:5275 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92993 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000172977 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Catalytic subunit of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H2A and H4. Histone acetylation alters nucleosome-DNA interactions and promotes interaction of the modified histones with other proteins which positively regulate transcription. The NuA4 histone acetyltransferase complex is required for the activation of transcriptional programs associated with proto-oncogene mediated growth induction, tumour suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR): the complex inhibits TP53BP1 binding to chromatin via MBTD1, which recognises and binds histone H4 trimethylated at 'Lys-20' (H4K20me), and KAT5 that catalyses acetylation of 'Lys-15' of histone H2A (H2AK15ac), thereby blocking the ubiquitination mark required for TP53BP1 localisation at DNA breaks. Also involved in DSB repair by mediating acetylation of 'Lys-5' of histone H2AX (H2AXK5ac), promoting NBN/NBS1 assembly at the sites of DNA damage. The NuA4 complex plays a key role in haematopoietic stem cell maintenance and is required to maintain acetylated H2A.Z/H2AZ1 at MYC target genes. Location: Nucleus; Chromosome; Cytoplasm; Chromosome, centromere, kinetochore (UniProt). Locus 11q13.1 (HGNC).
Query for this target: (TITLE:"KAT5" OR ABSTRACT:"KAT5" OR TITLE:"lysine acetyltransferase 5" OR ABSTRACT:"lysine acetyltransferase 5" OR TITLE:"Histone acetyltransferase KAT5" OR ABSTRACT:"Histone acetyltransferase KAT5" OR TITLE:"TIP60" OR ABSTRACT:"TIP60" OR TITLE:"cPLA2" OR ABSTRACT:"cPLA2" OR TITLE:"HTATIP1" OR ABSTRACT:"HTATIP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT5, not a curated reading list.