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KAT2B (Histone acetyltransferase KAT2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac).
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.94, genetic association 0.30).
In plain words · KAT2B (Histone acetyltransferase KAT2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
KAT2B (Histone acetyltransferase KAT2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles.
No product in this corpus aims at KAT2B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Yang X.-J. et al, Nature, 1996, "A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A". Source.
Sources: HGNC HGNC:8638 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92831 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114166 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm (UniProt). Locus 3p24.3 (HGNC).
Query for this target: (TITLE:"KAT2B" OR ABSTRACT:"KAT2B" OR TITLE:"lysine acetyltransferase 2B" OR ABSTRACT:"lysine acetyltransferase 2B" OR TITLE:"Histone acetyltransferase KAT2B" OR ABSTRACT:"Histone acetyltransferase KAT2B" OR TITLE:"P/CAF" OR ABSTRACT:"P/CAF" OR TITLE:"GCN5" OR ABSTRACT:"GCN5" OR TITLE:"GCN5L" OR ABSTRACT:"GCN5L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT2B, not a curated reading list.