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KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.80, animal model 0.30, genetic association 0.00).
In plain words · KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA.
No product in this corpus aims at KAT2A yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Candau et al, Mol. Cell. Biol, 1996, "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Source.
Sources: HGNC HGNC:4201 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92830 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108773 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 17q21.2 (HGNC).
Query for this target: (TITLE:"KAT2A" OR ABSTRACT:"KAT2A" OR TITLE:"lysine acetyltransferase 2A" OR ABSTRACT:"lysine acetyltransferase 2A" OR TITLE:"Histone acetyltransferase KAT2A" OR ABSTRACT:"Histone acetyltransferase KAT2A" OR TITLE:"GCN5" OR ABSTRACT:"GCN5" OR TITLE:"PCAF-b" OR ABSTRACT:"PCAF-b" OR TITLE:"GCN5L2" OR ABSTRACT:"GCN5L2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT2A, not a curated reading list.