Loading
KANK1 (KN motif and ankyrin repeat domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links structural and signalling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis. At focal adhesions (FAs) rims, organises cortical microtubule stabilising complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge. Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.76, genetic association 0.63).
In plain words · KANK1 (KN motif and ankyrin repeat domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
KANK1 (KN motif and ankyrin repeat domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links structural and signalling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis.
No product in this corpus aims at KANK1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:19309 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14678 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107104 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Adapter protein that links structural and signalling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis. At focal adhesions (FAs) rims, organises cortical microtubule stabilising complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge. Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex. Interacts with ARFGEF1 and participates in establishing microtubule-organising centre (MTOC) orientation and directed cell movement in wound healing. Regulates actin stress fibre formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signalling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Location: Cytoplasm, cell cortex; Cell projection, ruffle membrane; Cytoplasm; Nucleus (UniProt). Locus 9p24.3 (HGNC).
Query for this target: (TITLE:"KANK1" OR ABSTRACT:"KANK1" OR TITLE:"KN motif and ankyrin repeat domains 1" OR ABSTRACT:"KN motif and ankyrin repeat domains 1" OR TITLE:"KN motif and ankyrin repeat domain-containing protein 1" OR ABSTRACT:"KN motif and ankyrin repeat domain-containing protein 1" OR TITLE:"KIAA0172" OR ABSTRACT:"KIAA0172" OR TITLE:"ANKRD15" OR ABSTRACT:"ANKRD15") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KANK1, not a curated reading list.