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JAG2 (jagged canonical Notch ligand 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Putative Notch ligand involved in the mediation of Notch signalling. Involved in limb development.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.91, animal model 0.53, genetic association 0.00).
In plain words · JAG2 (jagged canonical Notch ligand 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
JAG2 (jagged canonical Notch ligand 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Putative Notch ligand involved in the mediation of Notch signalling. Involved in limb development.
No product in this corpus aims at JAG2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Luo et al, Mol. Cell. Biol, 1997, "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Source.
Sources: HGNC HGNC:6189 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y219 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184916 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0))
Putative Notch ligand involved in the mediation of Notch signalling. Involved in limb development. Location: Membrane (UniProt). Locus 14q32.33 (HGNC).
Query for this target: (TITLE:"JAG2" OR ABSTRACT:"JAG2" OR TITLE:"jagged canonical Notch ligand 2" OR ABSTRACT:"jagged canonical Notch ligand 2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about JAG2, not a curated reading list.