Loading
JAG1 (jagged canonical Notch ligand 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.78, animal model 0.59, genetic association 0.54).
In plain words · JAG1 (jagged canonical Notch ligand 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
JAG1 (jagged canonical Notch ligand 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis.
No product in this corpus aims at JAG1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Zimrin A.B. et al, J. Biol. Chem, 1996, "An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro". Source.
Sources: HGNC HGNC:6188 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78504 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000101384 (association with cancer (MONDO_0004992) 0.68; (GraphQL API, CC0))
Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Location: Membrane; Cell membrane (UniProt). Locus 20p12.2 (HGNC).
Query for this target: (TITLE:"JAG1" OR ABSTRACT:"JAG1" OR TITLE:"jagged canonical Notch ligand 1" OR ABSTRACT:"jagged canonical Notch ligand 1" OR TITLE:"HJ1" OR ABSTRACT:"HJ1" OR TITLE:"CD339" OR ABSTRACT:"CD339" OR TITLE:"JAGL1" OR ABSTRACT:"JAGL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about JAG1, not a curated reading list.