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ITPR1 (Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.94, animal model 0.58, genetic association 0.64).
In plain words · ITPR1 (Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ITPR1 (Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER).
No product in this corpus aims at ITPR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Yamada et al, Biochem. J, 1994, "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". Source.
Sources: HGNC HGNC:6180 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14643 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000150995 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. Regulates fertilisation and egg activation by tuning the frequency and amplitude of calcium oscillations. Location: Endoplasmic reticulum membrane; Cytoplasmic vesicle, secretory vesicle membrane; Cytoplasm, perinuclear region (UniProt). Locus 3p26.1 (HGNC).
Query for this target: (TITLE:"ITPR1" OR ABSTRACT:"ITPR1" OR TITLE:"inositol 1,4,5-trisphosphate receptor type 1" OR ABSTRACT:"inositol 1,4,5-trisphosphate receptor type 1" OR TITLE:"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1" OR ABSTRACT:"Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1" OR TITLE:"Insp3r1" OR ABSTRACT:"Insp3r1" OR TITLE:"IP3R1" OR ABSTRACT:"IP3R1" OR TITLE:"PPP1R94" OR ABSTRACT:"PPP1R94") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITPR1, not a curated reading list.