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ITGA2B (Integrin alpha-IIb) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.97, animal model 0.55, genetic association 0.07).
In plain words · ITGA2B (Integrin alpha-IIb) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ITGA2B (Integrin alpha-IIb) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands.
No product in this corpus aims at ITGA2B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1986. Earliest sequence paper UniProt cites for the protein: Charo I.F. et al, Proc. Natl. Acad. Sci. U.S.A, 1986, "Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells". Source.
Sources: HGNC HGNC:6138 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P08514 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000005961 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. Location: Cell membrane (UniProt). Locus 17q21.31 (HGNC).
Query for this target: (TITLE:"ITGA2B" OR ABSTRACT:"ITGA2B" OR TITLE:"integrin subunit alpha 2b" OR ABSTRACT:"integrin subunit alpha 2b" OR TITLE:"Integrin alpha-IIb" OR ABSTRACT:"Integrin alpha-IIb" OR TITLE:"CD41B" OR ABSTRACT:"CD41B" OR TITLE:"CD41" OR ABSTRACT:"CD41" OR TITLE:"PPP1R93" OR ABSTRACT:"PPP1R93") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITGA2B, not a curated reading list.