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IRX4 (Iroquois-class homeodomain protein IRX-4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Likely to be an important mediator of ventricular differentiation during cardiac development.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.84).
In plain words · IRX4 (Iroquois-class homeodomain protein IRX-4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
IRX4 (Iroquois-class homeodomain protein IRX-4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Likely to be an important mediator of ventricular differentiation during cardiac development. Location: Nucleus (UniProt).
No product in this corpus aims at IRX4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Lewis M.T. et al, 1997, "IRX: a new family of human homeobox genes from the breast". Source.
Sources: HGNC HGNC:6129 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78413 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000113430 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0))
Likely to be an important mediator of ventricular differentiation during cardiac development. Location: Nucleus (UniProt). Locus 5p15.33 (HGNC).
Query for this target: (TITLE:"IRX4" OR ABSTRACT:"IRX4" OR TITLE:"iroquois homeobox 4" OR ABSTRACT:"iroquois homeobox 4" OR TITLE:"Iroquois-class homeodomain protein IRX-4" OR ABSTRACT:"Iroquois-class homeodomain protein IRX-4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IRX4, not a curated reading list.