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IRS1 (Insulin receptor substrate 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Signalling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signalling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.83, animal model 0.51, genetic association 0.16).
In plain words · IRS1 (Insulin receptor substrate 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
IRS1 (Insulin receptor substrate 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Signalling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R.
No product in this corpus aims at IRS1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1992. Earliest sequence paper UniProt cites for the protein: Nishiyama et al, Biochem. Biophys. Res. Commun, 1992, "Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma". Source.
Sources: HGNC HGNC:6125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35568 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000169047 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Signalling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R. Plays therefore an important role in development, growth, glucose homeostasis as well as lipid metabolism. Upon phosphorylation by the insulin receptor, functions as a signalling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of PI3K, NCK1, NCK2, GRB2 or SHP2. Recruitment of GRB2 leads to the activation of the guanine nucleotide exchange factor SOS1 which in turn triggers the Ras/Raf/MEK/MAPK signalling cascade. Activation of the PI3K/AKT pathway is responsible for most of insulin metabolic effects in the cell, and the Ras/Raf/MEK/MAPK is involved in the regulation of gene expression and in cooperation with the PI3K pathway regulates cell growth and differentiation. Acts a positive regulator of the Wnt/beta-catenin signalling pathway through suppression of DVL2 autophagy-mediated degradation leading to cell proliferation. Location: Cytoplasm; Nucleus (UniProt). Locus 2q36.3 (HGNC).
Query for this target: (TITLE:"IRS1" OR ABSTRACT:"IRS1" OR TITLE:"insulin receptor substrate 1" OR ABSTRACT:"insulin receptor substrate 1" OR TITLE:"Insulin receptor substrate 1" OR ABSTRACT:"Insulin receptor substrate 1" OR TITLE:"HIRS-1" OR ABSTRACT:"HIRS-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IRS1, not a curated reading list.