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IRF5 (Interferon regulatory factor 5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.66).
In plain words · IRF5 (Interferon regulatory factor 5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
IRF5 (Interferon regulatory factor 5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9.
No product in this corpus aims at IRF5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Grossman et al, 1996. Source.
Sources: HGNC HGNC:6120 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13568 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000128604 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. Location: Cytoplasm; Nucleus (UniProt). Locus 7q32.1 (HGNC).
Query for this target: (TITLE:"IRF5" OR ABSTRACT:"IRF5" OR TITLE:"interferon regulatory factor 5" OR ABSTRACT:"interferon regulatory factor 5" OR TITLE:"Interferon regulatory factor 5" OR ABSTRACT:"Interferon regulatory factor 5" OR TITLE:"IRF-5" OR ABSTRACT:"IRF-5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IRF5, not a curated reading list.