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IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.98, genetic association 0.32, somatic mutation 0.00, animal model 0.58).
In plain words · IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton.
No product in this corpus aims at IQGAP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Weissbach et al, J. Biol. Chem, 1994, "Identification of a human rasGAP-related protein containing calmodulin-binding motifs". Source.
Sources: HGNC HGNC:6110 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P46940 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140575 (association with cancer (MONDO_0004992) 0.67; (GraphQL API, CC0))
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. Location: Cell membrane; Nucleus; Cytoplasm; Cytoplasm, cell cortex (UniProt). Locus 15q26.1 (HGNC).
Query for this target: (TITLE:"IQGAP1" OR ABSTRACT:"IQGAP1" OR TITLE:"IQ motif containing GTPase activating protein 1" OR ABSTRACT:"IQ motif containing GTPase activating protein 1" OR TITLE:"Ras GTPase-activating-like protein IQGAP1" OR ABSTRACT:"Ras GTPase-activating-like protein IQGAP1" OR TITLE:"p195" OR ABSTRACT:"p195" OR TITLE:"KIAA0051" OR ABSTRACT:"KIAA0051" OR TITLE:"SAR1" OR ABSTRACT:"SAR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IQGAP1, not a curated reading list.