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INHBB (Inhibin beta B chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, animal model 0.51, genetic association 0.70).
In plain words · INHBB (Inhibin beta B chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
INHBB (Inhibin beta B chain) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.
No product in this corpus aims at INHBB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1986. Earliest sequence paper UniProt cites for the protein: Mason A.J. et al, Biochem. Biophys. Res. Commun, 1986, "Structure of two human ovarian inhibins". Source.
Sources: HGNC HGNC:6067 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09529 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163083 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0))
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Activin B is a dimer of alpha and beta-B that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and wound healing. Signals through type I receptor ACVR1C, abundantly expressed in pancreatic beta cells, and type II receptors like ACVR2A or BMPR2. Upon ligand binding, these receptors phosphorylate intracellular signalling mediators SMAD2 and SMAD3, which form a complex with SMAD4, translocate to the nucleus, and regulate gene expression. Location: Secreted (UniProt). Locus 2q14.2 (HGNC).
Query for this target: (TITLE:"INHBB" OR ABSTRACT:"INHBB" OR TITLE:"inhibin subunit beta B" OR ABSTRACT:"inhibin subunit beta B" OR TITLE:"Inhibin beta B chain" OR ABSTRACT:"Inhibin beta B chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about INHBB, not a curated reading list.