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ING1 (Inhibitor of growth protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Colorectal cancer and Endometrial cancer.
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.49, somatic mutation 0.73, genetic literature 0.61). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma, Endometrial Carcinoma.
In plain words · ING1 (Inhibitor of growth protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Colorectal cancer and Endometrial cancer.
ING1 (Inhibitor of growth protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Colorectal cancer and Endometrial cancer.
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene.
No product in this corpus aims at ING1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Garkavtsev I.A. et al, Nat. Genet, 1996, "Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation". Source.
Sources: HGNC HGNC:6062 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UK53 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000153487 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: head and neck squamous cell carcinoma 0.59 (GraphQL API, CC0)); IntOGen ING1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene. Location: Nucleus (UniProt). Locus 13q34 (HGNC).
Query for this target: (TITLE:"ING1" OR ABSTRACT:"ING1" OR TITLE:"inhibitor of growth family member 1" OR ABSTRACT:"inhibitor of growth family member 1" OR TITLE:"Inhibitor of growth protein 1" OR ABSTRACT:"Inhibitor of growth protein 1" OR TITLE:"p33ING1" OR ABSTRACT:"p33ING1" OR TITLE:"p33ING1b" OR ABSTRACT:"p33ING1b" OR TITLE:"p24ING1c" OR ABSTRACT:"p24ING1c") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ING1, not a curated reading list.