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INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.50, genetic association 0.67).
In plain words · INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
No product in this corpus aims at INCENP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Adams R.R. et al, Chromosoma, 2001, "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells". Source.
Sources: HGNC HGNC:6058 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NQS7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000149503 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC. Location: Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle; Midbody (UniProt). Locus 11q12.3 (HGNC).
Query for this target: (TITLE:"INCENP" OR ABSTRACT:"INCENP" OR TITLE:"inner centromere protein" OR ABSTRACT:"inner centromere protein" OR TITLE:"Inner centromere protein" OR ABSTRACT:"Inner centromere protein" OR TITLE:"FLJ31633" OR ABSTRACT:"FLJ31633") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about INCENP, not a curated reading list.