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IL33 (Interleukin-33) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · IL33 (Interleukin-33) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
IL33 (Interleukin-33) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells.
No product in this corpus aims at IL33 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA IL33: RNA tissue enhanced (urinary bladder 114 nTPM); high antibody staining in 7 normal tissues; highest cancer staining glioma (4 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas IL33 tissue; Open Targets ENSG00000137033 associations
First described 1999. Earliest sequence paper UniProt cites for the protein: Onda et al, J. Cereb. Blood Flow Metab, 1999, "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage". Source.
Sources: HGNC HGNC:16028 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95760 (protein name, function text, keywords and locations (REST API)); CIViC gene IL33 (1 evidence items, 0 assertions, 1 variants; diseases: High Grade Glioma (GraphQL API, CC0))
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarisation of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Location: Nucleus; Chromosome; Cytoplasm; Cytoplasmic vesicle, secretory vesicle (UniProt). Locus 9p24.1 (HGNC).
RNA: tissue enhanced (urinary bladder 114 nTPM), detected in many normal tissues.
Medium: Appendix, Bone marrow, Breast, Cerebral cortex, Esophagus, Lymph node, Pancreas, Salivary gland.
Medium only: cervical cancer, head and neck cancer, stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IL33" OR ABSTRACT:"IL33" OR TITLE:"interleukin 33" OR ABSTRACT:"interleukin 33" OR TITLE:"Interleukin-33" OR ABSTRACT:"Interleukin-33" OR TITLE:"DVS27" OR ABSTRACT:"DVS27" OR TITLE:"DKFZp586H0523" OR ABSTRACT:"DKFZp586H0523" OR TITLE:"NF-HEV" OR ABSTRACT:"NF-HEV") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IL33, not a curated reading list.