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IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.91, animal model 0.40, genetic association 0.42, somatic mutation 0.72).
In plain words · IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.
No product in this corpus aims at IGF2R yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1987. Earliest sequence paper UniProt cites for the protein: Morgan D.O. et al, Nature, 1987, "Insulin-like growth factor II receptor as a multifunctional binding protein". Source.
Sources: HGNC HGNC:5467 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11717 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197081 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Location: Golgi apparatus membrane; Endosome membrane (UniProt). Locus 6q25.3 (HGNC).
Query for this target: (TITLE:"IGF2R" OR ABSTRACT:"IGF2R" OR TITLE:"insulin like growth factor 2 receptor" OR ABSTRACT:"insulin like growth factor 2 receptor" OR TITLE:"Cation-independent mannose-6-phosphate receptor" OR ABSTRACT:"Cation-independent mannose-6-phosphate receptor" OR TITLE:"CD222" OR ABSTRACT:"CD222" OR TITLE:"MPR1" OR ABSTRACT:"MPR1" OR TITLE:"CIMPR" OR ABSTRACT:"CIMPR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IGF2R, not a curated reading list.