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IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development.
CIViC holds 5 clinical evidence items and 0 assertions across 1 variant, naming Linsitinib, Cabazitaxel, Ganitumab and Docetaxel and others.
In plain words · IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals.
No product in this corpus aims at IGF2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA IGF2: RNA tissue enriched (placenta 2,598 nTPM); high antibody staining in 1 normal tissue; highest cancer staining urothelial cancer (2 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma); Open Targets associates it with 1 specific cancer type at or above 0.5 (Beckwith-Wiedemann syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas IGF2 tissue; Open Targets ENSG00000167244 associations
First described 1978. Earliest sequence paper UniProt cites for the protein: Rinderknecht et al, FEBS Lett, 1978, "Primary structure of human insulin-like growth factor II". Source.
Sources: HGNC HGNC:5466 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01344 (protein name, function text, keywords and locations (REST API)); CIViC gene IGF2 (5 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer, Ovarian Cancer, Pancreatic Adenocarcinoma (GraphQL API, CC0))
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Location: Secreted (UniProt). Locus 11p15.5 (HGNC).
RNA: tissue enriched (placenta 2,598 nTPM), detected in many normal tissues.
Medium: Kidney, Small intestine.
RNA cancer enhanced: Bladder Urothelial Carcinoma 958 pTPM, Ovary Serous Cystadenocarcinoma 1,031 pTPM.
Medium only: ovarian cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IGF2" OR ABSTRACT:"IGF2" OR TITLE:"insulin like growth factor 2" OR ABSTRACT:"insulin like growth factor 2" OR TITLE:"Insulin-like growth factor 2" OR ABSTRACT:"Insulin-like growth factor 2" OR TITLE:"FLJ44734" OR ABSTRACT:"FLJ44734" OR TITLE:"IGF-II" OR ABSTRACT:"IGF-II" OR TITLE:"C11orf43" OR ABSTRACT:"C11orf43") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IGF2, not a curated reading list.