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IFNGR1 (Interferon gamma receptor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signalling components JAK1 and JAK2.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Ipilimumab.
In plain words · IFNGR1 (Interferon gamma receptor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
IFNGR1 (Interferon gamma receptor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.
No product in this corpus aims at IFNGR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA IFNGR1: RNA low tissue specificity; high antibody staining in 14 normal tissues; highest cancer staining head and neck cancer (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas IFNGR1 tissue; Open Targets ENSG00000027697 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Aguet et al, Cell, 1988, "Molecular cloning and expression of the human interferon-gamma receptor". Source.
Sources: HGNC HGNC:5439 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15260 (protein name, function text, keywords and locations (REST API)); CIViC gene IFNGR1 (1 evidence items, 0 assertions, 2 variants; diseases: Melanoma (GraphQL API, CC0))
Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signalling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerisation, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. Location: Cell membrane (UniProt). Locus 6q23.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Bronchus, Colon, Gallbladder, Kidney.
Medium only: colorectal cancer, pancreatic cancer, testis cancer.
HPA IFNGR1 tissue · HPA IFNGR1 pathology · HPA protein class: CD markers, FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"IFNGR1" OR ABSTRACT:"IFNGR1" OR TITLE:"interferon gamma receptor 1" OR ABSTRACT:"interferon gamma receptor 1" OR TITLE:"Interferon gamma receptor 1" OR ABSTRACT:"Interferon gamma receptor 1" OR TITLE:"CD119" OR ABSTRACT:"CD119" OR TITLE:"IFNGR" OR ABSTRACT:"IFNGR") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about IFNGR1, not a curated reading list.