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HVCN1 (Voltage-gated hydrogen channel 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain. Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · HVCN1 (Voltage-gated hydrogen channel 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
HVCN1 (Voltage-gated hydrogen channel 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain.
No product in this corpus aims at HVCN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HVCN1: RNA tissue enriched (choroid plexus 505 nTPM); high antibody staining in 2 normal tissues; highest cancer staining lymphoma (1 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HVCN1 tissue; Open Targets ENSG00000122986 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Clark H.F. et al, Genome Res, 2003, "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Source.
Sources: HGNC HGNC:28240 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96D96 (protein name, function text, keywords and locations (REST API)); CIViC gene HVCN1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain. Appears to play a dominant role in regulation of CO2/HCO3(-)/H(+) equilibrium in sperm flagellum. Prevents the acidification resulting from HCO3(-) synthesis and thus sustains high HCO3(-) levels inside sperm for capacitation. Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst. Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa. Location: Cell membrane; Apical cell membrane; Cytoplasmic vesicle, phagosome membrane; Cell projection, cilium, flagellum membrane (UniProt). Locus 12q24.11 (HGNC).
RNA: tissue enriched (choroid plexus 505 nTPM), detected in all normal tissues.
Medium: Appendix, Colon, Rectum, Small intestine, Testis.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HVCN1" OR ABSTRACT:"HVCN1" OR TITLE:"hydrogen voltage gated channel 1" OR ABSTRACT:"hydrogen voltage gated channel 1" OR TITLE:"Voltage-gated hydrogen channel 1" OR ABSTRACT:"Voltage-gated hydrogen channel 1" OR TITLE:"MGC15619" OR ABSTRACT:"MGC15619" OR TITLE:"Hv1" OR ABSTRACT:"Hv1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HVCN1, not a curated reading list.