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HSPB1 (Heat shock protein beta-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organisation. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine.
In plain words · HSPB1 (Heat shock protein beta-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
HSPB1 (Heat shock protein beta-1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organisation.
No product in this corpus aims at HSPB1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HSPB1: RNA tissue enhanced (esophagus 6,919 nTPM); high antibody staining in 17 normal tissues; highest cancer staining skin cancer (4 of 9 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HSPB1 tissue; Open Targets ENSG00000106211 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Hickey et al, Nucleic Acids Res, 1986, "Sequence and organization of genes encoding the human 27 kDa heat shock protein". Source.
Sources: HGNC HGNC:5246 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04792 (protein name, function text, keywords and locations (REST API)); CIViC gene HSPB1 (1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Ductal Adenocarcinoma (GraphQL API, CC0))
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organisation. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 7q11.23 (HGNC).
RNA: tissue enhanced (esophagus 6,919 nTPM), detected in all normal tissues.
Medium: Adrenal gland, Cerebellum, Cervix, Duodenum, Kidney, Lung, Parathyroid gland, Prostate.
Medium only: liver cancer, melanoma, ovarian cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HSPB1" OR ABSTRACT:"HSPB1" OR TITLE:"heat shock protein family B small member 1" OR ABSTRACT:"heat shock protein family B small member 1" OR TITLE:"Heat shock protein beta-1" OR ABSTRACT:"Heat shock protein beta-1" OR TITLE:"HSP27" OR ABSTRACT:"HSP27" OR TITLE:"HSP28" OR ABSTRACT:"HSP28" OR TITLE:"Hs.76067" OR ABSTRACT:"Hs.76067") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSPB1, not a curated reading list.