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HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Temozolomide and Onalespib.
In plain words · HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
HSP90B1 (Endoplasmin) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport.
No product in this corpus aims at HSP90B1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA lists HSP90B1 among essential proteins; a medicine acting on the wild-type protein would expose normal tissue too. HPA HSP90B1: RNA tissue enhanced (thyroid gland 1,323 nTPM); high antibody staining in 32 normal tissues; highest cancer staining liver cancer (12 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HSP90B1 tissue; Open Targets ENSG00000166598 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Chang S.C. et al, Mol. Cell. Biol, 1989, "Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors". Source.
Sources: HGNC HGNC:12028 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14625 (protein name, function text, keywords and locations (REST API)); CIViC gene HSP90B1 (1 evidence items, 0 assertions, 1 variants; diseases: Glioma (GraphQL API, CC0))
ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport. Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway. When associated with CNPY3, required for proper folding of Toll-like receptors. Promotes folding and trafficking of TLR4 to the cell surface. May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10. Location: Endoplasmic reticulum lumen; Sarcoplasmic reticulum lumen; Melanosome (UniProt). Locus 12q23.3 (HGNC).
RNA: tissue enhanced (thyroid gland 1,323 nTPM), detected in all normal tissues.
Medium: Adipose tissue, Esophagus, Heart muscle, Liver, Lung, Lymph node, Oral mucosa, Salivary gland.
HPA HSP90B1 tissue · HPA HSP90B1 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HSP90B1" OR ABSTRACT:"HSP90B1" OR TITLE:"heat shock protein 90 beta family member 1" OR ABSTRACT:"heat shock protein 90 beta family member 1" OR TITLE:"Endoplasmin" OR ABSTRACT:"Endoplasmin" OR TITLE:"GP96" OR ABSTRACT:"GP96" OR TITLE:"GRP94" OR ABSTRACT:"GRP94" OR TITLE:"TRA1" OR ABSTRACT:"TRA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HSP90B1, not a curated reading list.