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HOXD13 (Homeobox protein Hox-D13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, animal model 0.82, genetic association 0.00, somatic mutation 0.93).
In plain words · HOXD13 (Homeobox protein Hox-D13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
HOXD13 (Homeobox protein Hox-D13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No product in this corpus aims at HOXD13 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: D'Esposito et al, Genomics, 1991, "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Source.
Sources: HGNC HGNC:5136 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35453 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000128714 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).
Query for this target: (TITLE:"HOXD13" OR ABSTRACT:"HOXD13" OR TITLE:"homeobox D13" OR ABSTRACT:"homeobox D13" OR TITLE:"Homeobox protein Hox-D13" OR ABSTRACT:"Homeobox protein Hox-D13" OR TITLE:"HOX4I" OR ABSTRACT:"HOX4I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXD13, not a curated reading list.