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HOXD11 (Homeobox protein Hox-D11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.71, animal model 0.32, genetic association 0.37, somatic mutation 0.94).
In plain words · HOXD11 (Homeobox protein Hox-D11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
HOXD11 (Homeobox protein Hox-D11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt).
No product in this corpus aims at HOXD11 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Acampora et al, Nucleic Acids Res, 1989, "The human HOX gene family". Source.
Sources: HGNC HGNC:5134 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31277 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000128713 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0))
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 2q31.1 (HGNC).
Query for this target: (TITLE:"HOXD11" OR ABSTRACT:"HOXD11" OR TITLE:"homeobox D11" OR ABSTRACT:"homeobox D11" OR TITLE:"Homeobox protein Hox-D11" OR ABSTRACT:"Homeobox protein Hox-D11" OR TITLE:"HOX4" OR ABSTRACT:"HOX4" OR TITLE:"HOX4F" OR ABSTRACT:"HOX4F") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXD11, not a curated reading list.