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HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, animal model 0.67, somatic mutation 0.77). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Invasive Breast Carcinoma.
In plain words · HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
HOXC13 (Homeobox protein Hox-C13) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer.
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
No product in this corpus aims at HOXC13 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1989. Earliest sequence paper UniProt cites for the protein: Acampora et al, Nucleic Acids Res, 1989, "The human HOX gene family". Source.
Sources: HGNC HGNC:5125 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31276 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000123364 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0)); IntOGen HOXC13 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes. Location: Nucleus (UniProt). Locus 12q13.13 (HGNC).
Query for this target: (TITLE:"HOXC13" OR ABSTRACT:"HOXC13" OR TITLE:"homeobox C13" OR ABSTRACT:"homeobox C13" OR TITLE:"Homeobox protein Hox-C13" OR ABSTRACT:"Homeobox protein Hox-C13" OR TITLE:"HOX3" OR ABSTRACT:"HOX3" OR TITLE:"HOX3G" OR ABSTRACT:"HOX3G") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXC13, not a curated reading list.