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HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.99, animal model 0.43, genetic association 0.10, somatic mutation 0.93).
In plain words · HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
HOXA11 (Homeobox protein Hox-A11) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt).
No product in this corpus aims at HOXA11 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1989. Earliest sequence paper UniProt cites for the protein: Acampora et al, Nucleic Acids Res, 1989, "The human HOX gene family". Source.
Sources: HGNC HGNC:5101 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P31270 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000005073 (association with cancer (MONDO_0004992) 0.61; (GraphQL API, CC0))
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 7p15.2 (HGNC).
Query for this target: (TITLE:"HOXA11" OR ABSTRACT:"HOXA11" OR TITLE:"homeobox A11" OR ABSTRACT:"homeobox A11" OR TITLE:"Homeobox protein Hox-A11" OR ABSTRACT:"Homeobox protein Hox-A11" OR TITLE:"HOX1I" OR ABSTRACT:"HOX1I" OR TITLE:"HOX1" OR ABSTRACT:"HOX1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXA11, not a curated reading list.