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HOOK3 (Protein Hook homolog 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.89, genetic association 0.00, somatic mutation 0.85).
In plain words · HOOK3 (Protein Hook homolog 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
HOOK3 (Protein Hook homolog 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin.
No product in this corpus aims at HOOK3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Walenta J.H. et al, J. Cell Biol, 2001, "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". Source.
Sources: HGNC HGNC:23576 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86VS8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168172 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Location: Cytoplasm, cytoskeleton; Golgi apparatus (UniProt). Locus 8p11.21 (HGNC).
Query for this target: (TITLE:"HOOK3" OR ABSTRACT:"HOOK3" OR TITLE:"hook microtubule tethering protein 3" OR ABSTRACT:"hook microtubule tethering protein 3" OR TITLE:"Protein Hook homolog 3" OR ABSTRACT:"Protein Hook homolog 3" OR TITLE:"HK3" OR ABSTRACT:"HK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOOK3, not a curated reading list.