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HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.63).
In plain words · HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
HNF4G (Hepatocyte nuclear factor 4-gamma) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.
No product in this corpus aims at HNF4G yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Drewes et al, Mol. Cell. Biol, 1996, "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Source.
Sources: HGNC HGNC:5026 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14541 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164749 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Transcription factor. Has a lower transcription activation potential than HNF4-alpha. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Query for this target: (TITLE:"HNF4G" OR ABSTRACT:"HNF4G" OR TITLE:"hepatocyte nuclear factor 4 gamma" OR ABSTRACT:"hepatocyte nuclear factor 4 gamma" OR TITLE:"Hepatocyte nuclear factor 4-gamma" OR ABSTRACT:"Hepatocyte nuclear factor 4-gamma" OR TITLE:"NR2A2" OR ABSTRACT:"NR2A2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNF4G, not a curated reading list.