Loading
HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1.
Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes genetic literature 0.92, affected pathway 0.35, literature 0.98, genetic association 0.88, animal model 0.25).
In plain words · HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
HNF1B (Hepatocyte nuclear factor 1-beta) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma and Ovarian cancer.
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene.
No product in this corpus aims at HNF1B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: Bach et al, Nucleic Acids Res, 1991, "Two members of an HNF1 homeoprotein family are expressed in human liver". Source.
Sources: HGNC HGNC:11630 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35680 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000275410 (association with cancer (MONDO_0004992) 0.77; per-cancer scores at or above 0.5: renal cell carcinoma 0.71, ovarian cancer 0.54 (GraphQL API, CC0))
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1. Location: Nucleus (UniProt). Locus 17q12 (HGNC).
Query for this target: (TITLE:"HNF1B" OR ABSTRACT:"HNF1B" OR TITLE:"HNF1 homeobox B" OR ABSTRACT:"HNF1 homeobox B" OR TITLE:"Hepatocyte nuclear factor 1-beta" OR ABSTRACT:"Hepatocyte nuclear factor 1-beta" OR TITLE:"LFB3" OR ABSTRACT:"LFB3" OR TITLE:"VHNF1" OR ABSTRACT:"VHNF1" OR TITLE:"HNF1beta" OR ABSTRACT:"HNF1beta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HNF1B, not a curated reading list.