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HMOX1 (Heme oxygenase 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
Catalyses the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolise free heme and prevent it from sensitising cells to undergo apoptosis. Catalyses the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants, naming Sorafenib and Sunitinib.
In plain words · HMOX1 (Heme oxygenase 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
HMOX1 (Heme oxygenase 1) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma.
Catalyses the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
No product in this corpus aims at HMOX1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HMOX1: RNA tissue enriched (lymphoid tissue 740 nTPM); blood lineage lineage enriched (monocytes 331 nTPM); high antibody staining in 6 normal tissues; highest cancer staining urothelial cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HMOX1 tissue; Open Targets ENSG00000100292 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Yoshida et al, Eur. J. Biochem, 1988, "Human heme oxygenase cDNA and induction of its mRNA by hemin". Source.
Sources: HGNC HGNC:5013 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09601 (protein name, function text, keywords and locations (REST API)); CIViC gene HMOX1 (1 evidence items, 0 assertions, 2 variants; diseases: Renal Cell Carcinoma (GraphQL API, CC0))
Catalyses the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolise free heme and prevent it from sensitising cells to undergo apoptosis. Catalyses the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. Location: Endoplasmic reticulum membrane (UniProt). Locus 22q12.3 (HGNC).
RNA: tissue enriched (lymphoid tissue 740 nTPM), detected in all normal tissues. Blood: lineage enriched (monocytes 331 nTPM).
Medium: Appendix, Lymph node, Placenta, Tonsil.
Medium only: glioma, liver cancer, renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HMOX1" OR ABSTRACT:"HMOX1" OR TITLE:"heme oxygenase 1" OR ABSTRACT:"heme oxygenase 1" OR TITLE:"Heme oxygenase 1" OR ABSTRACT:"Heme oxygenase 1" OR TITLE:"bK286B10" OR ABSTRACT:"bK286B10" OR TITLE:"HO-1" OR ABSTRACT:"HO-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HMOX1, not a curated reading list.