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HMGA1 (High mobility group protein HMG-I/HMG-Y) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, animal model 0.55, genetic association 0.37, somatic mutation 0.92).
In plain words · HMGA1 (High mobility group protein HMG-I/HMG-Y) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
HMGA1 (High mobility group protein HMG-I/HMG-Y) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts.
No product in this corpus aims at HMGA1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1987. Earliest sequence paper UniProt cites for the protein: Lund et al, Biochem. Biophys. Res. Commun, 1987, "The human chromosomal protein HMG I contains two identical palindrome amino acid sequences". Source.
Sources: HGNC HGNC:5010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17096 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137309 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. Location: Nucleus; Chromosome (UniProt). Locus 6p21.31 (HGNC).
Query for this target: (TITLE:"HMGA1" OR ABSTRACT:"HMGA1" OR TITLE:"high mobility group AT-hook 1" OR ABSTRACT:"high mobility group AT-hook 1" OR TITLE:"High mobility group protein HMG-I/HMG-Y" OR ABSTRACT:"High mobility group protein HMG-I/HMG-Y" OR TITLE:"HMGIY" OR ABSTRACT:"HMGIY") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HMGA1, not a curated reading list.