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HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, animal model 0.40, genetic association 0.67).
In plain words · HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
HHIP (Hedgehog-interacting protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt).
No product in this corpus aims at HHIP yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Huo et al, Gene Funct. Dis, 2000, "Determination of the chromosomal location and genomic structure of the Hedgehog-interacting protein gene, and analysis of its role in holoprosencephaly". Source.
Sources: HGNC HGNC:14866 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96QV1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164161 (association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: colorectal cancer 0.52 (GraphQL API, CC0))
Modulates hedgehog signalling in several cell types including brain and lung through direct interaction with members of the hedgehog family. Location: Cell membrane; Secreted; Cytoplasm (UniProt). Locus 4q31.21 (HGNC).
Query for this target: (TITLE:"HHIP" OR ABSTRACT:"HHIP" OR TITLE:"hedgehog interacting protein" OR ABSTRACT:"hedgehog interacting protein" OR TITLE:"Hedgehog-interacting protein" OR ABSTRACT:"Hedgehog-interacting protein" OR TITLE:"FLJ20992" OR ABSTRACT:"FLJ20992") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HHIP, not a curated reading list.