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HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.56, somatic mutation 0.68).
In plain words · HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
HERPUD1 (Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.
No product in this corpus aims at HERPUD1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Nomura et al, DNA Res, 1994, "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". Source.
Sources: HGNC HGNC:13744 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15011 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000051108 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. Location: Endoplasmic reticulum membrane (UniProt). Locus 16q13 (HGNC).
Query for this target: (TITLE:"HERPUD1" OR ABSTRACT:"HERPUD1" OR TITLE:"homocysteine inducible ER protein with ubiquitin like domain 1" OR ABSTRACT:"homocysteine inducible ER protein with ubiquitin like domain 1" OR TITLE:"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein" OR ABSTRACT:"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein" OR TITLE:"KIAA0025" OR ABSTRACT:"KIAA0025" OR TITLE:"Mif1" OR ABSTRACT:"Mif1" OR TITLE:"HERPUD1-IT1" OR ABSTRACT:"HERPUD1-IT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HERPUD1, not a curated reading list.