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HDAC8 (Histone deacetylase 8) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Histone deacetylase that catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, clinical 0.95).
In plain words · HDAC8 (Histone deacetylase 8) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
HDAC8 (Histone deacetylase 8) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Histone deacetylase that catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
No product in this corpus aims at HDAC8 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HDAC8: RNA low tissue specificity; high antibody staining in 6 normal tissues; highest cancer staining stomach cancer (1 of 8 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, peripheral T-cell lymphoma, not otherwise specified). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HDAC8 tissue; Open Targets ENSG00000147099 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Bonaldo M.F. et al, Genome Res, 1996, "Normalization and subtraction: two approaches to facilitate gene discovery". Source.
Sources: HGNC HGNC:13315 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BY41 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147099 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.57 (GraphQL API, CC0))
Histone deacetylase that catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones. Location: Nucleus; Chromosome; Cytoplasm (UniProt). Locus Xq13.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Appendix, Breast, Cerebral cortex, Colon, Duodenum, Endometrium, Epididymis, Esophagus.
Medium only: carcinoid, cervical cancer, endometrial cancer, glioma.
HPA HDAC8 tissue · HPA HDAC8 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HDAC8" OR ABSTRACT:"HDAC8" OR TITLE:"histone deacetylase 8" OR ABSTRACT:"histone deacetylase 8" OR TITLE:"Histone deacetylase 8" OR ABSTRACT:"Histone deacetylase 8" OR TITLE:"RPD3" OR ABSTRACT:"RPD3" OR TITLE:"KDAC8" OR ABSTRACT:"KDAC8" OR TITLE:"HDACL1" OR ABSTRACT:"HDACL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDAC8, not a curated reading list.