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HDAC7 (Histone deacetylase 7) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.31, genetic association 0.02, clinical 0.95).
In plain words · HDAC7 (Histone deacetylase 7) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
HDAC7 (Histone deacetylase 7) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
No product in this corpus aims at HDAC7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HDAC7: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 7 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, peripheral T-cell lymphoma, not otherwise specified). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HDAC7 tissue; Open Targets ENSG00000061273 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Li et al, 2000, "A novel class II HDAC is associated with the transcriptional homeodomain repressor CCAAT displacement protein". Source.
Sources: HGNC HGNC:14067 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WUI4 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000061273 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.58 (GraphQL API, CC0))
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.11 (HGNC).
RNA: low tissue specificity, detected in all normal tissues. Blood: lineage enriched (granulocytes 7 nTPM).
No normal tissue stained high.
No cancer sample stained medium or high.
HPA HDAC7 tissue · HPA HDAC7 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HDAC7" OR ABSTRACT:"HDAC7" OR TITLE:"histone deacetylase 7" OR ABSTRACT:"histone deacetylase 7" OR TITLE:"Histone deacetylase 7" OR ABSTRACT:"Histone deacetylase 7" OR TITLE:"DKFZP586J0917" OR ABSTRACT:"DKFZP586J0917" OR TITLE:"HDAC7A" OR ABSTRACT:"HDAC7A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDAC7, not a curated reading list.