Loading
HDAC5 (Histone deacetylase 5) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, clinical 0.95).
In plain words · HDAC5 (Histone deacetylase 5) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
HDAC5 (Histone deacetylase 5) is a protein that switches other genes on and off. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma and Multiple myeloma.
In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).
No product in this corpus aims at HDAC5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA HDAC5: RNA low tissue specificity; high antibody staining in 9 normal tissues; highest cancer staining colorectal cancer (1 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Multiple myeloma); Open Targets associates it with 2 specific cancer types at or above 0.5 (plasma cell myeloma, peripheral T-cell lymphoma, not otherwise specified). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HDAC5 tissue; Open Targets ENSG00000108840 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:14068 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UQL6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108840 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: plasma cell myeloma 0.55, non-Hodgkin lymphoma 0.56 (GraphQL API, CC0))
In vitro, it deacetylates lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Location: Nucleus; Cytoplasm (UniProt). Locus 17q21.31 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Adrenal gland, Breast, Cerebellum, Cerebral cortex, Cervix, Endometrium, Epididymis.
Medium only: breast cancer, cervical cancer, endometrial cancer, glioma.
HPA HDAC5 tissue · HPA HDAC5 pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HDAC5" OR ABSTRACT:"HDAC5" OR TITLE:"histone deacetylase 5" OR ABSTRACT:"histone deacetylase 5" OR TITLE:"Histone deacetylase 5" OR ABSTRACT:"Histone deacetylase 5" OR TITLE:"KIAA0600" OR ABSTRACT:"KIAA0600" OR TITLE:"NY-CO-9" OR ABSTRACT:"NY-CO-9" OR TITLE:"FLJ90614" OR ABSTRACT:"FLJ90614") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDAC5, not a curated reading list.