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HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
HBB (Haemoglobin subunit beta) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
No product in this corpus aims at HBB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HBB: RNA tissue enriched (bone marrow 125,481 nTPM); blood lineage group enriched (dendritic cells 381 nTPM, granulocytes 662 nTPM); no normal tissue stained high; highest cancer staining carcinoid (1 of 3 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas HBB tissue; Open Targets ENSG00000244734 associations
First described 1957. Earliest sequence paper UniProt cites for the protein: Ingram V.M., Nature, 1957, "Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin". Source.
Sources: HGNC HGNC:4827 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P68871 (protein name, function text, keywords and locations (REST API)); CIViC gene HBB (1 evidence items, 0 assertions, 1 variants; diseases: SMARCB1-deficient Renal Medullary Carcinoma (GraphQL API, CC0))
Involved in oxygen transport from the lung to the various peripheral tissues. LVV-haemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure. Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signalling, these properties implicate it as a regulator of pain and inflammation. Locus 11p15.4 (HGNC).
RNA: tissue enriched (bone marrow 125,481 nTPM), detected in all normal tissues. Blood: group enriched (dendritic cells 381 nTPM, granulocytes 662 nTPM).
No normal tissue stained high; medium in Bone marrow, Lung, Placenta.
RNA cancer enhanced: Glioblastoma Multiforme 1,324 pTPM.
Medium only: cervical cancer, colorectal cancer, liver cancer, lung cancer.
HPA HBB tissue · HPA HBB pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HBB" OR ABSTRACT:"HBB" OR TITLE:"hemoglobin subunit beta" OR ABSTRACT:"hemoglobin subunit beta" OR TITLE:"Hemoglobin subunit beta" OR ABSTRACT:"Hemoglobin subunit beta" OR TITLE:"CD113t-C" OR ABSTRACT:"CD113t-C" OR TITLE:"beta-globin" OR ABSTRACT:"beta-globin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HBB, not a curated reading list.