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H4C9 (Histone H4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes affected pathway 0.76, animal model 0.46, somatic mutation 0.49). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.
In plain words · H4C9 (Histone H4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.
H4C9 (Histone H4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
No product in this corpus aims at H4C9 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1983. Earliest sequence paper UniProt cites for the protein: Sierra et al, Nucleic Acids Res, 1983, "Structure and in vitro transcription of a human H4 histone gene". Source.
Sources: HGNC HGNC:4793 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P62805 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000276180 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0)); IntOGen H4C9 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).
Query for this target: (TITLE:"H4C9" OR ABSTRACT:"H4C9" OR TITLE:"H4 clustered histone 9" OR ABSTRACT:"H4 clustered histone 9" OR TITLE:"Histone H4" OR ABSTRACT:"Histone H4" OR TITLE:"H4/m" OR ABSTRACT:"H4/m" OR TITLE:"H4FM" OR ABSTRACT:"H4FM" OR TITLE:"HIST1H4I" OR ABSTRACT:"HIST1H4I") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H4C9, not a curated reading list.