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H2AC6 (Histone H2A type 1-C) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H2AC6 (Histone H2A type 1-C) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
H2AC6 (Histone H2A type 1-C) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.
No product in this corpus aims at H2AC6 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA lists H2AC6 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA H2AC6: RNA low tissue specificity; blood lineage lineage enriched (granulocytes 1,567 nTPM); high antibody staining in 13 normal tissues; highest cancer staining glioma (10 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas H2AC6 tissue; Open Targets ENSG00000180573 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Ruddy D.A. et al, Genome Res, 1997, "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Source.
Sources: HGNC HGNC:4733 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q93077 (protein name, function text, keywords and locations (REST API)); CIViC gene H2AC6 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
RNA: low tissue specificity, detected in many normal tissues. Blood: lineage enriched (granulocytes 1,567 nTPM).
Medium: Adipose tissue, Adrenal gland, Appendix, Breast, Bronchus, Cervix, Colon, Endometrium.
Medium only: carcinoid, cervical cancer, endometrial cancer, head and neck cancer.
HPA H2AC6 tissue · HPA H2AC6 pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H2AC6" OR ABSTRACT:"H2AC6" OR TITLE:"H2A clustered histone 6" OR ABSTRACT:"H2A clustered histone 6" OR TITLE:"Histone H2A type 1-C" OR ABSTRACT:"Histone H2A type 1-C" OR TITLE:"H2AFL" OR ABSTRACT:"H2AFL" OR TITLE:"HIST1H2AC" OR ABSTRACT:"HIST1H2AC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H2AC6, not a curated reading list.