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H1-3 (Histone H1.3) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · H1-3 (Histone H1.3) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
H1-3 (Histone H1.3) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre.
No product in this corpus aims at H1-3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA H1-3: RNA tissue enhanced (bone marrow 20 nTPM, choroid plexus 7 nTPM); high antibody staining in 29 normal tissues; highest cancer staining lymphoma (9 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas H1-3 tissue; Open Targets ENSG00000124575 associations
First described 1989. Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1989, "Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d". Source.
Sources: HGNC HGNC:4717 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16402 (protein name, function text, keywords and locations (REST API)); CIViC gene H1-3 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0))
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).
RNA: tissue enhanced (bone marrow 20 nTPM, choroid plexus 7 nTPM), detected in many normal tissues.
Medium: Adipose tissue, Breast, Cerebral cortex, Fallopian tube, Gallbladder, Heart muscle, Hippocampus, Liver.
RNA cancer enhanced: Bladder Urothelial Carcinoma 10 pTPM, Colon Adenocarcinoma 11 pTPM.
Medium only: breast cancer, head and neck cancer, lung cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"H1-3" OR ABSTRACT:"H1-3" OR TITLE:"H1.3 linker histone, cluster member" OR ABSTRACT:"H1.3 linker histone, cluster member" OR TITLE:"Histone H1.3" OR ABSTRACT:"Histone H1.3" OR TITLE:"H1.3" OR ABSTRACT:"H1.3" OR TITLE:"H1d" OR ABSTRACT:"H1d" OR TITLE:"H1s-2" OR ABSTRACT:"H1s-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about H1-3, not a curated reading list.