Loading
GTF2I (General transcription factor II-I) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thymoma.
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Thymoma.
In plain words · GTF2I (General transcription factor II-I) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thymoma.
GTF2I (General transcription factor II-I) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Thymoma.
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes.
No product in this corpus aims at GTF2I yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1997. Earliest sequence paper UniProt cites for the protein: Roy A.L. et al, EMBO J, 1997, "Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1". Source.
Sources: HGNC HGNC:4659 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78347 (protein name, function text, keywords and locations (REST API)); IntOGen GTF2I (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Location: Cytoplasm; Nucleus (UniProt). Locus 7q11.23 (HGNC).
Query for this target: (TITLE:"GTF2I" OR ABSTRACT:"GTF2I" OR TITLE:"general transcription factor IIi" OR ABSTRACT:"general transcription factor IIi" OR TITLE:"General transcription factor II-I" OR ABSTRACT:"General transcription factor II-I" OR TITLE:"TFII-I" OR ABSTRACT:"TFII-I" OR TITLE:"BAP-135" OR ABSTRACT:"BAP-135" OR TITLE:"BTKAP1" OR ABSTRACT:"BTKAP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GTF2I, not a curated reading list.