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GRHL2 (Grainyhead-like protein 2 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.32, genetic association 0.60).
In plain words · GRHL2 (Grainyhead-like protein 2 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
GRHL2 (Grainyhead-like protein 2 homolog) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes.
No product in this corpus aims at GRHL2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:2799 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ISB3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000083307 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: breast cancer 0.52 (GraphQL API, CC0))
Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure. Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components. Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localisation at tight junctions. Location: Nucleus; Membrane (UniProt). Locus 8q22.3 (HGNC).
Query for this target: (TITLE:"GRHL2" OR ABSTRACT:"GRHL2" OR TITLE:"grainyhead like transcription factor 2" OR ABSTRACT:"grainyhead like transcription factor 2" OR TITLE:"Grainyhead-like protein 2 homolog" OR ABSTRACT:"Grainyhead-like protein 2 homolog" OR TITLE:"FLJ13782" OR ABSTRACT:"FLJ13782" OR TITLE:"DFNA28" OR ABSTRACT:"DFNA28" OR TITLE:"TFCP2L3" OR ABSTRACT:"TFCP2L3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GRHL2, not a curated reading list.