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GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
Cell surface proteoglycan that bears heparan sulfate.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.54, somatic mutation 0.43). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cholangiocarcinoma, Ovarian Epithelial Tumour.
In plain words · GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
GPC5 (Glypican-5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Ovarian cancer and Biliary tract cancer.
Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt).
No product in this corpus aims at GPC5 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1997. Earliest sequence paper UniProt cites for the protein: Veugelers et al, Genomics, 1997, "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family". Source.
Sources: HGNC HGNC:4453 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P78333 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179399 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0)); IntOGen GPC5 (driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cell surface proteoglycan that bears heparan sulfate. Location: Cell membrane; Secreted, extracellular space (UniProt). Locus 13q31.3 (HGNC).
Query for this target: (TITLE:"GPC5" OR ABSTRACT:"GPC5" OR TITLE:"glypican 5" OR ABSTRACT:"glypican 5" OR TITLE:"Glypican-5" OR ABSTRACT:"Glypican-5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GPC5, not a curated reading list.