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GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.31, animal model 0.39, genetic association 0.04, somatic mutation 0.92).
In plain words · GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
GOPC (Golgi-associated PDZ and coiled-coil motif-containing protein) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels.
No product in this corpus aims at GOPC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Neudauer C.L. et al, Biochem. Biophys. Res. Commun, 2001, "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Source.
Sources: HGNC HGNC:17643 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HD26 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000047932 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR. Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane; Synapse (UniProt). Locus 6q22.1 (HGNC).
Query for this target: (TITLE:"GOPC" OR ABSTRACT:"GOPC" OR TITLE:"golgi associated PDZ and coiled-coil motif containing" OR ABSTRACT:"golgi associated PDZ and coiled-coil motif containing" OR TITLE:"Golgi-associated PDZ and coiled-coil motif-containing protein" OR ABSTRACT:"Golgi-associated PDZ and coiled-coil motif-containing protein" OR TITLE:"dJ94G16.2" OR ABSTRACT:"dJ94G16.2" OR TITLE:"GOPC1" OR ABSTRACT:"GOPC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOPC, not a curated reading list.