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GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.76, genetic association 0.38).
In plain words · GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
GOLGA4 (Golgin subfamily A member 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1.
No product in this corpus aims at GOLGA4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Seelig H.P., 1994. Source.
Sources: HGNC HGNC:4427 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13439 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000144674 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking. Location: Cytoplasm; Golgi apparatus membrane; Golgi apparatus, trans-Golgi network membrane (UniProt). Locus 3p22.2 (HGNC).
Query for this target: (TITLE:"GOLGA4" OR ABSTRACT:"GOLGA4" OR TITLE:"golgin A4" OR ABSTRACT:"golgin A4" OR TITLE:"Golgin subfamily A member 4" OR ABSTRACT:"Golgin subfamily A member 4" OR TITLE:"golgin-245" OR ABSTRACT:"golgin-245" OR TITLE:"GCP2" OR ABSTRACT:"GCP2" OR TITLE:"p230" OR ABSTRACT:"p230") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GOLGA4, not a curated reading list.