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GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion. Ghrelin binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.16, clinical 0.92).
In plain words · GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
GHSR (Growth hormone secretagogue receptor type 1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion.
No product in this corpus aims at GHSR yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GHSR: RNA tissue enriched (pituitary gland 4 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas GHSR tissue; Open Targets ENSG00000121853 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Howard A.D. et al, Science, 1996, "A receptor in pituitary and hypothalamus that functions in growth hormone release". Source.
Sources: HGNC HGNC:4267 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92847 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000121853 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach. Upon activation, stimulates appetite and promotes growth hormone secretion. Ghrelin binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. GHSR is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Also binds other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. Location: Cell membrane (UniProt). Locus 3q26.31 (HGNC).
RNA: tissue enriched (pituitary gland 4 nTPM), detected in single normal tissue.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GHSR" OR ABSTRACT:"GHSR" OR TITLE:"growth hormone secretagogue receptor" OR ABSTRACT:"growth hormone secretagogue receptor" OR TITLE:"Growth hormone secretagogue receptor type 1" OR ABSTRACT:"Growth hormone secretagogue receptor type 1" OR TITLE:"GHS-R1a" OR ABSTRACT:"GHS-R1a" OR TITLE:"GHS-R" OR ABSTRACT:"GHS-R" OR TITLE:"GHSR-1a" OR ABSTRACT:"GHSR-1a") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GHSR, not a curated reading list.