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GALNT14 (Polypeptide N-acetylgalactosaminyltransferase 14) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
CIViC holds 1 clinical evidence item and 0 assertions across 2 variants.
In plain words · GALNT14 (Polypeptide N-acetylgalactosaminyltransferase 14) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
GALNT14 (Polypeptide N-acetylgalactosaminyltransferase 14) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.
Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.
No product in this corpus aims at GALNT14 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA GALNT14: RNA tissue enhanced (kidney 39 nTPM); blood lineage lineage enriched (granulocytes 9 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Hepatocellular carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas GALNT14 tissue; Open Targets ENSG00000158089 associations
First described 2003. Earliest sequence paper UniProt cites for the protein: Wang et al, Biochem. Biophys. Res. Commun, 2003, "Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14". Source.
Sources: HGNC HGNC:22946 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96FL9 (protein name, function text, keywords and locations (REST API)); CIViC gene GALNT14 (1 evidence items, 0 assertions, 2 variants; diseases: Hepatocellular Carcinoma (GraphQL API, CC0))
Catalyses the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. Location: Golgi apparatus membrane (UniProt). Locus 2p23.1 (HGNC).
RNA: tissue enhanced (kidney 39 nTPM), detected in many normal tissues. Blood: lineage enriched (granulocytes 9 nTPM).
No normal tissue stained high.
RNA group enriched: Kidney Renal Clear Cell Carcinoma 117 pTPM, Kidney Renal Papillary Cell Carcinoma 97 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"GALNT14" OR ABSTRACT:"GALNT14" OR TITLE:"polypeptide N-acetylgalactosaminyltransferase 14" OR ABSTRACT:"polypeptide N-acetylgalactosaminyltransferase 14" OR TITLE:"Polypeptide N-acetylgalactosaminyltransferase 14" OR ABSTRACT:"Polypeptide N-acetylgalactosaminyltransferase 14" OR TITLE:"GalNac-T10" OR ABSTRACT:"GalNac-T10" OR TITLE:"FLJ12691" OR ABSTRACT:"FLJ12691" OR TITLE:"GalNac-T14" OR ABSTRACT:"GalNac-T14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GALNT14, not a curated reading list.