Loading
FXR1 (RNA-binding protein FXR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.89, genetic association 0.00).
In plain words · FXR1 (RNA-binding protein FXR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FXR1 (RNA-binding protein FXR1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis.
No product in this corpus aims at FXR1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Siomi M.C. et al, EMBO J, 1995, "FXR1, an autosomal homolog of the fragile X mental retardation gene". Source.
Sources: HGNC HGNC:4023 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51114 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000114416 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids. Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site. Acts as a negative regulator of inflammation in response to IL19 by promoting destabilisation of pro-inflammatory transcripts. Location: Cytoplasm, Cytoplasmic ribonucleoprotein granule; Cytoplasm, Stress granule; Cytoplasm; Cell projection, dendrite (UniProt). Locus 3q26.33 (HGNC).
Query for this target: (TITLE:"FXR1" OR ABSTRACT:"FXR1" OR TITLE:"FMR1 autosomal homolog 1" OR ABSTRACT:"FMR1 autosomal homolog 1" OR TITLE:"RNA-binding protein FXR1" OR ABSTRACT:"RNA-binding protein FXR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FXR1, not a curated reading list.