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FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.76, genetic association 0.23).
In plain words · FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases.
No product in this corpus aims at FRS3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Xu et al, J. Biol. Chem, 1998, "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". Source.
Sources: HGNC HGNC:16970 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43559 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137218 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2. Location: Membrane (UniProt). Locus 6p21.1 (HGNC).
Query for this target: (TITLE:"FRS3" OR ABSTRACT:"FRS3" OR TITLE:"fibroblast growth factor receptor substrate 3" OR ABSTRACT:"fibroblast growth factor receptor substrate 3" OR TITLE:"Fibroblast growth factor receptor substrate 3" OR ABSTRACT:"Fibroblast growth factor receptor substrate 3" OR TITLE:"SNT-2" OR ABSTRACT:"SNT-2" OR TITLE:"FRS2beta" OR ABSTRACT:"FRS2beta" OR TITLE:"FRS2B" OR ABSTRACT:"FRS2B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FRS3, not a curated reading list.