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FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcriptional repressor that represses lung-specific expression.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.61, somatic mutation 0.28).
In plain words · FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt).
No product in this corpus aims at FOXP4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2002. Earliest sequence paper UniProt cites for the protein: Daigo et al, 2002, "Isolation, mapping, and characterization of a novel human cDNA differentially expressed in the fundus of W/Wv mutant mice". Source.
Sources: HGNC HGNC:20842 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IVH2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000137166 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt). Locus 6p21.1 (HGNC).
Query for this target: (TITLE:"FOXP4" OR ABSTRACT:"FOXP4" OR TITLE:"forkhead box P4" OR ABSTRACT:"forkhead box P4" OR TITLE:"Forkhead box protein P4" OR ABSTRACT:"Forkhead box protein P4" OR TITLE:"FLJ40908" OR ABSTRACT:"FLJ40908") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXP4, not a curated reading list.